REJEUNESSE FINE

Medi N Research engineered Rejeunesse Fine with Lidocaine as a high-purity, non-animal origin hyaluronic acid filler. This specific formulation targets fine to medium facial wrinkles and subtle contour refinement through a concentration of 24 mg/mL cross-linked HA and 0.3% lidocaine. Its soft, monophasic gel structure facilitates uniform distribution across delicate regions, including the periorbital area and forehead lines.

Practitioners often prioritize this variant for early-stage rejuvenation where they do not require substantial tissue expansion. Furthermore, the proprietary manufacturing process employs advanced cross-linking technology to reduce endotoxin levels and remove residual BDDE. Consequently, the gel achieves exceptional purity and maintains stable integration within the superficial dermis.

Product Specification

Key Benefits

• Smooths fine to medium facial wrinkles
• Supports skin hydration through water-binding hyaluronic acid
• Suitable for delicate and thin-skinned treatment areas
• Contains 0.3% lidocaine to help improve injection comfort
• Monophasic gel texture allows smooth and even application
• Natural-looking correction without excessive volume
• Non-animal origin hyaluronic acid
• Low endotoxin level with no detectable residual BDDE
• Effects may last approximately 8–12 months depending on patient factors and treatment area

Application Areas

• Forehead lines
• Glabellar lines (frown lines)
• Crow’s feet and periocular wrinkles
• Perioral lines and smoker’s lines
• Nasolabial folds
• Lip contour refinement
• Neck lines
• Mild facial wrinkles
• Skin hydration support
• Subtle facial contour correction

Treatment Scope of Rejeunesse Fine

The product is designed for superficial wrinkle correction and mild age-related skin changes. It may be used for:

• Prevention and correction of early fine lines
• Improvement of skin texture and hydration balance
• Soft correction of superficial facial folds
• Lip border definition
• Periorbital wrinkle correction
• Mild rejuvenation of the face and neck

For deeper folds or stronger volumizing effects, practitioners often consider alternatives such as Rejeunesse Deep or Rejeunesse Shape.

Strengths of Rejeunesse Fine

1. Smooth Injection Performance: The filler has a relatively low reticulation structure, which may help reduce injection resistance and support precise placement in thin or delicate areas.
2. Hydration-Focused Formula: Hyaluronic acid naturally attracts water molecules, helping improve skin moisture and soften superficial lines after treatment.
3. Purity and Safety Profile: Rejeunesse Fine is produced using purified cross-linking technology with low endotoxin content and no detectable residual BDDE. The formula is also free from animal-derived ingredients.
4. Comfortable Procedure: The inclusion of 0.3% lidocaine helps reduce discomfort during injection, especially in sensitive regions such as the perioral and periocular areas.
5. Natural-Looking Correction: The monophasic gel integrates evenly into the skin, which may help avoid irregular texture or excessive projection after treatment.

Injection Areas and Technique

Practitioners primarily target the superficial to mid-dermis when administering Rejeunesse Fine. Because the gel possesses a low viscosity, it integrates seamlessly into the extracellular matrix without causing visible displacement.

Advanced Injection Techniques

Professional results rely on precise placement depth:

Linear Threading: Continuous deposition along the length of a wrinkle, ideal for forehead lines and nasolabial folds.

Serial Puncture: Small, isolated boluses along a treatment line ensure even distribution in high-movement periorbital zones.

Microinjection (Nappage): Utilized for broad rejuvenation and hydration across the forehead or the dorsum of the hands.

Needle Selection & Handling

While some techniques utilize a 27G needle, the manufacturer standardizes Rejeunesse Fine with ultra-thin 30G needles. This gauge significantly reduces mechanical tissue trauma and post-procedural bruising. Furthermore, the monophasic structure ensures a consistent extrusion force, which is particularly vital for delicate perioral “smoker’s lines”.

Patient Comfort & Safety

The integration of 0.3% lidocaine hydrochloride blunts the pain response directly at the injection site, enhancing patient tolerance. Because the formula contains no animal-derived components, patients do not require pre-treatment skin tests. The gel is sterile and pyrogen-free, effectively limiting immunogenic reactions.

Storage & Maintenance

• To preserve molecular integrity, clinicians must store the product between 2°C and 25°C (36°F to 77°F).
• Exposure to sunlight or freezing temperatures can compromise viscoelastic properties.
• Syringes, sterile should remain in original packaging until use to ensure clinical efficacy.
• Single-use only

Technical SummaryTarget Depth:

• Superficial to mid-dermis
• Included Equipment: 2 x 30G sterile needles
• Anesthetic Content: 0.3% Lidocaine HCl
• Safety Profile: Non-animal origin; Pyrogen-free; CE Certified

Technology and Manufacturing

Newmedic Co., Ltd. manufactures Rejeunesse Fine using a sophisticated combination of UPHEC purification and the DIAMOLD production process. This dual-pillar approach prioritizes structural gel stability and chemical purity over aggressive tissue volumization.

To maintain clinical safety, the production facility adheres strictly to ISO 13485 and Korean Good Manufacturing Practice (KGMP) standards. Laboratory documentation confirms that endotoxin levels consistently stay below 1.2 EU/mL, while the purification cycle eliminates all detectable residual BDDE (1,4-butanediol diglycidyl ether).

Through the proprietary UPHEC (Unique Purification for High Efficacy and Continuity) method, the manufacturer implements a rigorous, multi-stage filtration system. This technology effectively strips away chemical impurities that might otherwise trigger post-procedural edema or delayed inflammatory responses in sensitive patients. Consequently, practitioners can rely on a highly predictable safety profile during superficial injections.

Furthermore, the DIAMOLD production process refines the shape and consistency of the hyaluronic acid particles. This ensures that the gel maintains its intended position within the dermis without migrating or losing its shape under mechanical stress.

Regarding long-term efficacy, the HCCL (High Concentration of Cross-Linking) technology establishes a robust 100% cross-linked matrix. While standard thin fillers often succumb quickly to enzymatic stress, this dense molecular structure resists hyaluronidase with significantly higher efficiency.

Clinical observations indicate that the corrective properties of Rejeunesse Fine persist for 8 to 12 months. Accordingly, this structural durability reduces the necessity for frequent maintenance sessions and enhances overall patient satisfaction.

Professional Use Notice

Must use by licensed medical professionals trained in aesthetic injection procedures. Product selection, injection depth, and treatment technique should always be based on individual patient anatomy and clinical assessment.